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Prof. Dr. habil. Hans Börner
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+49 (0)30 2093-7348 |
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+49 (0)30 2093-7500 |
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Contact Us |
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Laboratory for Organic Synthesis of Functional Systems
Department of Chemistry
Humboldt-Universität zu Berlin
Brook-Taylor-Str. 2
12489 Berlin
Germany
Sekretariat
Phone: +49 (0)30 2093-7349
Fax: +49 (0)30 2093-7215
Room: 0'144
Email
office.functional-systems hu-berlin.de
Anfahrt
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Group Members
Dr. Sebastian Wieczorek
Post-Doc
Group of Prof. Börner
Department of Chemistry
Humboldt-Universität zu Berlin
Brook-Taylor-Str. 2, 12489 Berlin
Lab: 3'117
Phone: +49 (0)30 2093-7464
Email: sebastian.wieczorek hu-berlin.de
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Curriculum Vitae
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25.12.1982 |
born in Berlin, Germany |
10/2005 - 03/2011 |
Chemistry studies (B.Sc./M.Sc.) at Freie Universität Berlin, Germany |
02/2009 - 05/2009 |
Bachelor research thesis at Freie Universität Berlin under guidance of Prof. Dr. Koksch, „Analytical investigation on a-helical coiled coil forming beta- and gamma amino acid containing chimeras“ |
10/2010 - 01/2011
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Master research thesis at Freie Universität Berlin under guidance of Prof. Dr. Koksch, „Selecting preferred interaction partners of homologated amino acids in a chimeric coiled coil motif: An application of phage display” |
02/2011 - 04/2016
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Doctoral research at Humboldt-Universität zu Berlin under guidance of Prof. Hans Börner, „Ein kombinatorischer Ansatz zur Entwicklung von spezifischen Löslichkeitsvermittlern für niedermolekulare Wirkstoffe“ |
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Publications
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1. |
S. Wieczorek, A. Dallmann, Z. Kochovski, H. G. Börner
„Advancing drug-formulation additives toward precision additives with release mediating peptide interlayer”
Journal of the American Chemical Society 2016, DOI: 10.1021/jacs.6b03604. |
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C. Lawatscheck, M. Pickhardt, S. Wieczorek, A. Grafmüller, E. Mandelkow, H. G. Börner, „Generalizing the concept of specific drug formulation additives toward non-fluorescent entities: A solubilization study on Alzheimer drugs”
Angewandte Chemie 2016, DOI: 10.1002/anie.201601147. |
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F. Zabihi, S. Wieczorek, M. Dimde, S. Hedtrich, H. G. Börner, R. Haag „Intradermal Drug Delivery by Nanogel-Peptide Conjugates; Specific and Efficient Transport of Temoporfin”
Journal of Controlled Release 2016, DOI:10.1016/j.jconrel.2016.07.033. |
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S. Wieczorek, S. Vigne, T. Masini, D. Ponader, L. Hartmann, A. K. H. Hirsch, H. G. Börner
„Combinatorial screening for specific drug transporters with switchable release profiles”
Macromolecular Bioscience 2015, 15, 82 – 89. |
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S. Wieczorek, T. Schwaar, M. O. Senge, H. G. Börner „Specific drug formulation additives: Revealing the impact of architecture and block length ratio”
Biomacromolecules 2015, 16 (10), 3308 – 3312. |
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M. Meißler, S. Wieczorek, N. ten Brummelhuis, H. G. Börner „Synthesis Aspects of Peptide- and Protein-Polymer Conjugates in the Pos-Click Era“
In Bio-inspired polymers; N. Bruns, A. F. M. Kilbinger, Eds.; Royal Society of Chemistry: London, UK, 2015, accepted. |
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N. ten Brummelhuis, S. Wieczorek, P. Wilke, T. Schwemmer, H. G. Börner
„Peptide-polymer conjugates as model systems to explore the functional space of precision polymers”
In Sequence-Controlled Polymers: Synthesis, Self-Assembly, and Properties; J. F. Lutz, T. Y. Meyer, M. Ouchi, M. Sawamoto, Eds.; ACS Symposium Serie 1170, American Chemical Society: Washington, DC, 2014; 55–69. |
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E. K. Nyakatura, R. R. Araghi, J. Mortier, S. Wieczorek, C. Baldauf, G. Wolber, B. Koksch
„An unusual interstrand H-bond stabilizes the hetero-assembly of helical αβγ-chimeras with natural peptides”
ACS Chemical Biology 2014, 9 (3), 613-616. |
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E. K. Nyakatura, J. Mortier, V. Radtke, S. Wieczorek, R. R. Araghi, C. Baldauf, G. Wolber, B. Koksch „β- and γ-Amino Acids at α-Helical Interfaces: Towards the Formation of Highly Stable Foldameric Coiled Coils”
ACS Medicinal Chemistry Letters 2014, 5 (12), 1300-1303. |
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S. Wieczorek, E. Krause, S. Hackbarth, B. Roeder, A. K. H. Hirsch, H. G. Börner „Exploiting specific interactions toward next-generation polymeric drug transporters”
Journal of the American Chemical Society 2013, 135 (5), 1711-1714. |
11. |
R. R. Araghi, C. Jackel, H. Cölfen, M. Salwiczek, A. Völkel, S. C. Wagner, S. Wieczorek, C. Baldauf, B. Koksch „A β/γ Motif to Mimic α-Helical Turns in Proteins”
ChemBioChem 2010, 11, 335-339. |
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